CTCF regulates the local epigenetic state of ribosomal DNA repeats

Abstract Background CCCTC binding factor (CTCF) is a highly conserved zinc finger protein, which is involved in chromatin organization, local histone modifications, and RNA polymerase II-mediated gene transcription.CTCF may act by binding tightly to DNA and recruiting other proteins to mediate its various functions in the nucleus.To further explore

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Current treatments for acute heart failure: focus on serelaxin

Robert G BennettVA Nebraska-Western Iowa Health Care System and Department of Internal Medicine, University of Nebraska Medical Center, Omaha, NE, USAAbstract: Acute heart failure remains an enormous health concern worldwide, and is a major cause of death and hospitalization.In spite of this, the treatment strategies for acute heart failure have re

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